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. 2022 Jul 2;11(13):2099. doi: 10.3390/cells11132099

Figure 5.

Figure 5

Resection in DNA-PKcs deficient and wild-type cells is entirely dependent on CtIP and MRE11. (A) Western blot analysis of CtIP levels in A549 wt and DNA-PKcs−/− cells after transfection with a siRNA targeting CtIP, or a non-specific control siRNA. (B) As in Figure 1D for A549 wt and DNA-PKcs−/− cells following CtIP depletion and exposure to 10 Gy of IR. (C) As in Figure 1E for the results shown in panel (B). (D) As in panel (B), for cells treated with a cocktail of the MRE11 inhibitors mirin and PFM01. (E) As in panel (C) for the results shown in panel (D). ** indicates p < 0.01, *** indicates p < 0.001 and **** indicates p < 0.0001.