Cigarette smoking |
∼1.7-fold increased risk compared with never smokers |
13–16
|
Obesity |
∼1.6-fold increased risk in individuals with obesity compared with those with normal weight |
39,40,42
|
Alcohol use |
1.6-fold increased risk in those consuming >6 drinks per day compared with those consuming >1 drink per day |
45–49
|
New-onset diabetes |
<0.3–0.8% of patients with new-onset diabetes develop pancreatic ductal adenocarcinoma within 3 years of diabetes diagnosis |
31–33
|
Long-standing diabetes |
1.5–2-fold increased risk of pancreatic cancer for individuals with diabetes of >3 years in duration |
26–30
|
Family history of pancreatic cancer |
Twofold increased risk in individuals with a single family member with pancreatic cancer compared with the general population; sevenfold increased risk in individuals with multiple family members with pancreatic cancer compared with the general population |
78
|
Pancreatitis |
Twofold to threefold increased risk in individuals with long-standing chronic pancreatitis |
50–52
|
Allergy |
25% lower risk of developing pancreatic cancer |
53–56
|