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. Author manuscript; available in PMC: 2022 Jul 8.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2021 May 17;18(7):493–502. doi: 10.1038/s41575-021-00457-x

Table 1 |.

Pancreatic cancer risk factors

Risk factor Associated risk of pancreatic cancer Refs
Cigarette smoking ∼1.7-fold increased risk compared with never smokers 1316
Obesity ∼1.6-fold increased risk in individuals with obesity compared with those with normal weight 39,40,42
Alcohol use 1.6-fold increased risk in those consuming >6 drinks per day compared with those consuming >1 drink per day 4549
New-onset diabetes <0.3–0.8% of patients with new-onset diabetes develop pancreatic ductal adenocarcinoma within 3 years of diabetes diagnosis 3133
Long-standing diabetes 1.5–2-fold increased risk of pancreatic cancer for individuals with diabetes of >3 years in duration 2630
Family history of pancreatic cancer Twofold increased risk in individuals with a single family member with pancreatic cancer compared with the general population; sevenfold increased risk in individuals with multiple family members with pancreatic cancer compared with the general population 78
Pancreatitis Twofold to threefold increased risk in individuals with long-standing chronic pancreatitis 5052
Allergy 25% lower risk of developing pancreatic cancer 5356