Table 1.
Summary of findings identified from microglial RNA sequencing studies.
| Experiment | Species & Location | Disease State | Marker Gene(S) | Pathways | Reference |
|---|---|---|---|---|---|
| Single-cell RNA-seq | Mouse spine, and brain cortex | HIV | Ifit2, Ifit3 | Interferon Signaling | [6] |
| Single-cell RNA-seq | Mouse spine, and brain cortex | HIV | Lpl, Cst7, Igf1 | Myelination | [6] |
| Single-nucleus RNA-seq | Human prefrontal cortex | AD | FTL, SPP1, SLC11A1, RPL28, TMEM163, C1QC | Neutrophil- mediated immunity, protein folding, intrinsic apoptotic signaling pathway, and regulation of protein stability | [33] |
| Single-cell RNA-seq | Mouse brain | AD | Lpl, Cst7 | Phagocytosis, lipid metabolism | [34] |
| Single-cell RNA-seq | Mouse brainstem | ALS | Camk2b | Regulation of Rac protein signal transduction, peptidyl lysine modification | [35] |
| Single-cell RNA-seq | Human CSF | HIV | C1QC, APOE, MSR1 | N/A | [36] |