Table 2.

Summary of findings from astrocytic RNA sequencing studies. Marker genes in bold are increased. Marker genes that are only italicized are decreased. WT: Wild-type.

Experiment	Species & Tissue Location	Disease State	Marker Gene(S)	Pathways	Reference
Single-nucleus RNA-seq	Human prefrontal cortex	AD	MT2A, MT1E, GJA1, LINGO1, RASGEF1B	Protein localisation, protein translation, protein stabilisation	[33]
Single-cell RNA-seq	Mouse brainstem	ALS	Mt1, Mt2, Fam107a, Malat1	Neurogenesis, regulation of cell projection organization, neuron differentiation	[35]
Single-cell RNA-seq	Mouse cortical layers	WT	Unc13c	Insulin signaling	[76]
Single-cell RNA-seq	Mouse cortex and hippocampus	WT	Agt, Gfap, Unc13c	Transcription regulators	[76]
Single-cell RNA-seq	Mouse hippocampus	WT	Frzb, Ascl1	Mitosis and cell cycle regulation, neural tissue development	[76]
Single-cell RNA-seq	Mouse cortex and hippocampus	WT	Fam107a	Glucose metabolism, energy production, neural tissue development	[76]
Single-cell RNA-seq	Mouse hippocampus	WT	Gfap, Agt	Synaptogenesis, synaptic plasticity, glutamatergic neurotransmission	[76]
Single-cell RNA-seq	Mouse brain	LPS treatment	Serpina3n	Adaptive immune response, NF-kB signalling	[77]
Single-nucleus RNA-seq	Human prefrontal cortex	AD	ADGRV1, GPC5, RYR3	Synaptic signaling, glutamate secretion	[78]