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. 2022 Jul 5;11(13):2118. doi: 10.3390/cells11132118

Figure 1.

Figure 1

The correlation between the NF-κB-SHh-GLI1 axis and poor clinical outcome in PCa. (A) Histogram and sample density (dotted line) plots of p65, SHh and GLI1 expression levels in patients with prostate adenocarcinoma from the TCGA dataset (n = 380). (B,C) Shown are the correlations between p65 and SHh mRNA expression (B) and GLI1 and SHh mRNA expression (C) in patients from (A). Pearson’s correlation values and p-values are shown. (D) Progression Free Interval (PFI) curves in patients from (A) stratified based on tumor-associated p65-SHh-GLI1 signature expression using the 75th percentile as a stratification threshold. (E) Box plots showing the expression levels of the p65-SHh-GLI1 signature in patients with a Gleason score <8 (black, n = 252) and ≥8 (red, n = 128) from (A). Shown in the box plots are the mean (horizontal lines), mean ± SEM (box outlines), or mean ± SD (vertical lines). Statistical significance was calculated by the 2-tailed Student’s t-test. * p < 0.05.