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. 2022 Jun 25;11(13):2025. doi: 10.3390/cells11132025

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematics showing domains and binding proteins of talin (A), RIAM (B), and kindlin (C). Integrin-NPXY: Asn-Pro-x-Tyr motifs of the β-integrin tail; Integrin MP region: membrane-proximal region of the β-integrin tail; Integrin-NxxY/F: Asn-x-x-Tyr/Phe motifs of the β-integrin tail; PIP2: phosphatidylinositol 4,5-bisphosphate; PIP3: phosphatidylinositol-3,4,5-triphosphate; Profilin-Actin: direct binding to profilin and indirect binding to actin. Created in BioRender.com (accessed on 12 June 2022).