Table 2.
Univariate and multivariate Cox regression models evaluating the influence of stromal (ST) or intra-tumoral (IT) of CD8, FoxP3, and CD68 on RFS and OS. Zero and one are related to the cutoff.
| Univariate Analysis | Relapse-Free Survival | Overall Survival | ||
|---|---|---|---|---|
| p-Value | HR (95% CI) | p-Value | HR (95% CI) | |
| CD8 ST 0-1 $ | 0.958 | 0.98 (0.48–2.02) | 0.026 # | 3.19 (1.15–8.90) |
| CD8 IT 1-0 | 0.011 | 3.73 (1.35–10.31) | 0.025 | 3.20 (1.16–8.84) |
| FoxP3 ST 1-0 | 0.002 | 1.97 (1.28–3.04) | 0.002 | 1.95 (1.29–2.96) |
| FoxP3 IT 1-0 | 0.008 | 1.84 (1.17–2.87) | 0.001 | 2.16 (1.36–3.41) |
| CD68 ST 1-0 | 0.206 | 1.56 (0.78–3.11) | 0.076 | 2.12 (0.93–4.85) |
| CD68 IT 0-1 | 0.004 | 1.86 (1.21–2.85) | 0.005 | 1.79 (1.19–2.69) |
| Multivariate Analysis | Relapse-Free Survival | Overall Survival | ||
| p-Value | HR (95% CI) | p-Value | HR (95% CI) | |
| CD8 ST 0-1 | 0.847 | 1.10 (0.43–2.78) | 0.028 | 5.03 (1.19–21.31) |
| CD8 IT 1-0 | 0.024 | 3.36 (1.17–9.67) | 0.038 | 3.08 (1.06–8.94) |
| FoxP3 ST 1-0 | 0.255 | 1.87 (0.64–5.49) | 0.147 | 2.46 (0.73–8.28) |
| FoxP3 IT 1-0 | 0.056 | 1.88 (0.98–3.57) | 0.109 | 1.63 (0.90–2.98) |
| CD68 ST 1-0 | 0.13 | 1.63 (0.86–3.09) | 0.961 | 1.02 (0.56–1.83) |
| CD68 IT 0-1 | 0.6 | 1.22 (0.58–2.55) | 0.080 | 1.98 (0.92–4.27) |