Table 3.
Sensitivity and specificity values for the detection of specific IgE to penicillin G and amoxicillin by ImmunoCAP® comparing different cut-offs.
| Pencillin sIgE (PG and/or AX sIgE) |
PG sIgE | AX sIgE | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cut-Off | Sens (SP) | Sens (IT) | p 1 | Spec | Sens (SP) | Sens (IT) | p 1 | Spec | Sens (SP) | Sens (IT) | p 1 | Spec |
| sIgE ≥ 0.1 kUA/L |
39.6% (N = 139) |
52.4% (N = 250) |
0.0197 | 68.8% (N = 32) |
15.1% (N = 139) |
30.4% (N = 250) |
0.0009 | 81.3% (N = 32) |
38.9% (N = 139) |
46.0% (N = 250) |
ns | 75.0% (N = 32) |
| sIgE ≥ 0.35 kUA/L |
15.8% (N = 139) |
32.4% (N = 250) |
0.0003 | 93.8% (N = 32) |
6.5% (N = 139) |
19.2% (N = 250) |
0.0005 | 96.9% (N = 32) |
14.4% (N = 139) |
26.0% (N = 250) |
0.0101 | 93.8% (N = 32) |
| sIgE/tIgE ≥ 0.002 |
13.7% (N = 139) |
35.7% (N = 244) |
<0.0001 | 81.3% (N = 32) |
8.6% (N = 139) |
20.1% (N = 244) |
0.0034 | 87.5% (N = 32) |
12.2% (N = 139) |
29.5% (N = 244) |
0.0001 | 90.6% (N = 32) |
1 Differences were considered statistically significant if p ≤ 0.05. Bonferroni correction alpha = 0.017. IT: Italy; sens: sensitivity; sIgE: specific IgE; SP: Spain; spec: specificity; tIgE: total Ig.