Table 4.
Clinical characteristic of patients with painless-diabetic neuropathy and ion channel gene variant.
| Sex | Age | DM Type | Age of Onset DM | Age of Onset Neuropathy | Potential Underlying Cause of Neuropathy | TTT | Positive Family History for Neuropathy | Variant |
|---|---|---|---|---|---|---|---|---|
| M | 78 | DM2 | 55 | - | - | - | No | ANO1 p.(Arg631Gln) |
| M | 68 | DM2 | 64 | - | - | - | - | KCNK18 p.(Phe139Trpfs*25) |
| M | 50 | DM2 | 46 | - | - | - | No | KCNK18 p.(Tyr121Leufs*44) |
| M | 73 | DM2 | 57 | - | - | - | - | KCNK18 p.(Tyr121Leufs*44) |
| M | 69 | DM1 | 13 | - | - | - | - | KCNQ3 p.(Pro409Arg) |
| F | 61 | DM1 | 32 | 61 | Thyroidectomy | Abnormal (feet) | Yes | TRPA1 p.(Leu118Val) |
| F | 39 | DM2 | 26 | - | - | - | - | TRPA1 p.(Phe660Leu) |
| M | 81 | DM2 | 66 | 78 | Hypothyroidism | Abnormal (hands and feet) | No | TRPM8 p.(Val986Ile) |
| M | 54 | DM1 | 7 | - | - | - | - | TRPV1 p.(Gly484Arg) |
| F | 62 | DM2 | 60 | - | - | - | - | TRPV1 p.(Ala594Val) |
| M | 43 | DM1 | 17 | 35 | Unknown | Abnormal (hands and feet) | Yes | TRPV1 p.(Thr597Met) |
| M | 76 | DM1 | 23 | 66 | Slipped disc LS 5/S1 | Normal | No | TRPV4 p.? |
| M | 52 | DM2 | 50 | - | - | - | - | TRPV4 p.(Arg320*) |
| M | 67 | DM2 | 67 | 68 | - | Normal | No | TRPV4 p.(Asp347Tyr) |
DM, diabetes mellitus; DM1, diabetes mellitus type 1; DM2, diabetes mellitus type 2; F, female; M, male; -, data incomplete. Age given at the day of recruitment visit.