Figure 3.

Crystal oligomer of bovine arrestin-2 in the presence of IP₆. Based on PDB ID 1ZSH [68]. Arrestin-2 oligomer in the presence of IP6 appears to form the same “infinite” chains in solution [69], with each protomer in basal conformation, crystal structure of which was solved earlier (PDB ID 1G4M [26] and 1ZSH [27]). Arrestin-2 in crystal forms “infinite” chains with no apparent limit. Three molecules making IP₆-mediated N-to-C contacts are shown. In each protomer arrestin-2 elements are colored, as follows: N-domain (residues 1–172), blue; inter-domain hinge (residues 173–184), yellow; C-domain (residues 185–352), green; C-tail (from residue 353), red (note the gap, as part of this element was not resolved in the crystal structure). Image was created in DS ViewerPro 6.0 (Dassault Systèmes, San Diego, CA, USA).