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. 2022 Jul 2;23(13):7392. doi: 10.3390/ijms23137392

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The hallmark gene sets of molecular pathways in response to 5-demethyl NOB treatment. (a) The top eight hallmark gene sets of molecular pathways associated with genes downregulated by 5-demethyl NOB. (b) GSEA demonstrates that the signature “Hallmark” gene set is enriched in the DEGs by 5-demethyl NOB treatment. (c) THP-1 cells were pretreated for 1 h with vehicle or 5-demethyl NOB and then incubated with LPS (10 ng/mL) for 24 h. p-p65, p65, TNF-α and actin proteins were detected by Western blot analysis. A representative blot is shown.

The hallmark gene sets of molecular pathways in response to 5-demethyl NOB treatment. (a) The top eight hallmark gene sets of molecular pathways associated with genes downregulated by 5-demethyl NOB. (b) GSEA demonstrates that the signature “Hallmark” gene set is enriched in the DEGs by 5-demethyl NOB treatment. (c) THP-1 cells were pretreated for 1 h with vehicle or 5-demethyl NOB and then incubated with LPS (10 ng/mL) for 24 h. p-p65, p65, TNF-α and actin proteins were detected by Western blot analysis. A representative blot is shown.