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. 2022 Jul 2;23(13):7392. doi: 10.3390/ijms23137392

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A hypothetical mechanism of the antileukemic effects of 5-demethyl NOB in human AML cells. 5-Demethyl NOB inhibits leukemia cell proliferation through the regulation of cell cycle arrest, apoptosis, cell differentiation, cell growth, and the NF-κB/TNF-α-mediated inflammatory response. 5-Demethyl NOB regulates cell proliferation through a substantial reduction in ID1 expression in AML cells. Cytarabine combined with 5-demethyl NOB showed a synergistic effect on the reduction of cell viability in AML cells.