Table 4.
Associations between prenatal urinary organophosphorus-pesticide metabolite concentrations and child’s preschool ADHD in a nested case–cohort study of the Norwegian Mother, Father and Child Cohort (MoBa), birth years 2004–2008.
| OP Metabolite |
Case | Sub-Cohort | Log10OR (95% CI) |
Case | Sub-Cohort | Q1 (Ref) OR (95% CI) |
Case | Sub- Cohort |
Q2 OR (95% CI) |
Case | Sub-Cohort | Q3 OR (95% CI) |
Case | Sub-Cohort | Q4 OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ∑DEP0 | 259 | 547 | 0.76 (0.52, 1.09) |
72 | 129 | ref | 62 | 140 | 0.79 (0.52, 1.20) |
67 | 135 | 0.89 (0.59, 1.34) |
58 | 143 | 0.73 (0.48, 1.11) |
| ∑DEP1 | 231 | 483 | 1.08 (0.67, 1.75) |
66 | 117 | ref | 56 | 124 | 0.96 (0.59, 1.56) |
58 | 115 | 1.13 (0.69, 1.85) |
51 | 127 | 0.94 (0.55, 1.61) |
| ∑DMP0 | 259 | 547 | 0.65 (0.49, 0.88) |
77 | 124 | ref | 63 | 139 | 0.73 (0.48, 1.10) |
67 | 135 | 0.80 (0.53, 1.20) |
52 | 149 | 0.56 (0.37, 0.86) |
| ∑DMP1 | 231 | 483 | 0.79 (0.53, 1.17) |
73 | 111 | ref | 52 | 127 | 0.75 (0.47, 1.19) |
59 | 119 | 0.88 (0.54, 1.42) |
47 | 126 | 0.75 (0.44, 1.26) |
Note: Log10OR, OR per log10-unit increase in concentration of OP metabolite; ref, reference; Q1, quartile 1; Q2, quartile 2; Q3, quartile 3; Q4, quartile 4; CI, confidence interval; ∑ DEP, sum of diethylphosphates metabolites; ∑ DMP, sum of dimethylphosphates metabolites; OR, odds ratio. Model 0, unadjusted; Model 1 adjusted for maternal education, parity, maternal income dependency, maternal age, marital status, maternal ADHD-like symptoms, pesticide use, fruit consumption, raw vegetable consumption, and season; all adjusted models were mutually adjusted for complementary DAP metabolite group.