Table 5.
Assessment of modification by variation in PON1 single-nucleotide polymorphism genotypes and child sex.
| Genotypes | n Cases/Sub-Cohort | Log10DEP (OR 95% CI) |
p-Interaction | Log10DMP (OR 95% CI) |
p-Interaction |
|---|---|---|---|---|---|
| PON1 L55M (maternal rs854560) | |||||
| MM (AA) | 100/213 | 0.67 (0.35, 1.27) | 0.40 | 0.66 (0.40, 1.11) | 0.77 |
| LM (TA) or LL (TT) | 144/306 | 0.94 (0.58, 1.51) | 0.73 (0.49, 1.09) | ||
| PON1 Q192R (maternal rs662) | |||||
| QQ (TT) | 124/279 | 0.74 (0.44, 1.26) | 0.43 | 0.68 (0.45, 1.04) | 0.72 |
| QR (TC) or RR (CC) | 123/243 | 1.01 (0.57, 1.79) | 0.76 (0.48, 1.21) | ||
| Child sex at birth | |||||
| Male | 144/271 | 0.73 (0.43, 1.24) | 0.45 | 0.74 (0.54, 1.00) | 0.83 |
| Female | 114/267 | 0.98 (0.57, 1.69) | 0.72 (0.47, 1.10) |
Note: PON1, paraoxonase 1; DEP, diethylphosphate metabolites; DMP, dimethylphosphate metabolites; OR, odds ratio; p-interaction, p-value for the interaction term; each model adjusted for specific gravity, maternal age, maternal education level, parity (reduced to most parsimonious model); models were mutually adjusted for complementary DAP metabolite group.