Table 5.

Toxicity models of the antiviral compounds and the reference drug.

Comp.	128	130	156	180	184	203	204	278	Simeprevir
FDA rodent carcinogenicity	Non-Carcinogen
Median carcinogenic potency (TD50), mg/kg/day	2.871	1.854	5.663	8.687	3.037	7.360	12.564	12.946	2.014
Rat maximum tolerated dose, g/kg body weight	2.382	1.277	0.137	0.002	0.021	0.018	0.029	0.020	0.003
Rat lethal dose (LD50) g/kg body weight	4.282	5.717	10.020	0.274	4.897	0.141	0.324	0.166	0.209
Rat chronic lowest observed adverse effect level (LOAEL), g/kg body weight	0.040	0.017	0.017	0.001	0.012	0.001	0.001	0.001	0.002
Ocular irritancy	Mild	Mild	Moderate	Moderate	None	Mild	Mild	Mild	Mild
Skin irritancy	Mild	Mild	Moderate	Mild	None	Mild	Mild	None	None