Correlation between BID and annexin levels in sera-cultured astrocytes and brain volume. (a,b) Correlation between BID RQ expression levels of mouse astrocytes following culture with sera of AQP4+ patients and (a) total cerebrum volume (r = −0.62, p = 0.0412), (b) total cerebellum volume (r = −0.88, p = 0.0003), (c,d) correlation between annexin levels of mouse astrocytes following culture with sera of AQP4+ patients and (c) total cerebellum volume (r = −0.78, p = 0.0068), (d) total brainstem volume (=−0.81, p = 0.0038). Correlation was determined by Pearson correlation test. Differences were considered significant at p < 0.05.