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Status of tumor spheroid formation and stem cell marker expression in Mlh1/1638N COL model. (A) The tumor spheroid number is increased in the resistant 5-FU-R phenotype relative to the sensitive 5-FU-S phenotype. (B) The expression of CD44, CD133 and c-Myc is increased in the resistant 5-FU-R phenotype relative to the sensitive 5-FU-S phenotype. 5-FU, 5-fluro-uracil; CD44, cluster of differentiation 44; CD133, cluster of differentiation 133; c-Myc, cellular Myc.
