Figure 5.

LY500307 treatment reduced the tumor initiation capacity of OCSCs. SKOV3 ALDH+ve cells that stable expressing GFP-Luc were treated with vehicle or LY500307 for 72 h, and the varying number of viable cells were injected into ovarian bursa. Mice were monitored for tumor establishment for 30 days and imaged weekly using Xenogen in vivo imaging system. (A) Table showing the mice per each group and number of mice with tumor establishment. (B) ELDA analysis was performed to estimate the tumorigenic capacity of OCSCs. (C,D) Pictures of the mice at the end of the experiment were shown.