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. 2022 Jun 21;23(13):6884. doi: 10.3390/ijms23136884

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Tri-, tetra-, and pentahexosylceramides of the globo-series. The three GSLs are exemplarily portrayed with a ceramide (Cer) moiety carrying sphingosine (d18:1) and a C16:0 fatty acyl chain. The GSLs were drawn with the program ChemDraw 2019, Version 19.1.1.21 (PerkinElmer Informatices, Inc., Waltham, MA, USA) and the sugars are depicted in the chair conformation. Declining adhesion strength of Stx1a and Stx2a along with increasing sugar chain length of the globo-series glycans is indicated: strong binding of Stx1a and Stx2a to Gb3Cer (), weak binding to Gb4Cer (), and no binding at all to Gb5Cer ().

Inline graphic — Tri-, tetra-, and pentahexosylceramides of the globo-series. The three GSLs are exemplarily portrayed with a ceramide (Cer) moiety carrying sphingosine (d18:1) and a C16:0 fatty acyl chain. The GSLs were drawn with the program ChemDraw 2019, Version 19.1.1.21 (PerkinElmer Informatices, Inc., Waltham, MA, USA) and the sugars are depicted in the chair conformation. Declining adhesion strength of Stx1a and Stx2a along with increasing sugar chain length of the globo-series glycans is indicated: strong binding of Stx1a and Stx2a to Gb3Cer (), weak binding to Gb4Cer (), and no binding at all to Gb5Cer ().