Table 1.

Tumor classification based on immune context.

Classification	T Cell Infiltration	Immunoscore	Strategies for Immunotherapy
Hot tumor	High (center)	High	T cell targeting (targeting immune checkpoint)
Altered-excluded	Low (center) High (invasive margin)	Intermediate	T cell trafficking (chemokines, e.g., C-X-C motif chemokine 9/10/11) Inhibit physical barrier
Altered- immunosuppressive	Intermediate (center) Low (invasive margin)	Intermediate	Inhibitors of soluble immunosuppressive factors Immunosuppressive cells (e.g., myeloid-derived suppressor cells, regulatory T cells) Modulation of innate immune sensing
Cold	Absent	Low	Convert to hot (radiotherapy, chemotherapy) Adoptive cell transfer Oncolytic viruses Vaccine-based therapy