Serial PET/CT evaluation during lymphoma course: (A) Baseline staging PET/CT: left submandibular, right axillary, paraortic, bilateral iliac and left inguinal lymphadenopathy (SUVmax of 35.8 at the left inguinal area). (B) Interim PET/CT after 2 cycles of ABVD: persistent disease at the initial sites, new left supraclavicular, subcarinal, hepatic portal, peripancreatic and right posterior diaphragmatic lymph node and spleen infiltration [SUVmax of 33, Deauville-5-point scale score (D5PSS) 5]. (C) Response assessment after 3 cycles of R-CHOP: slight 18FDG uptake in the left inguinal area (SUVmax of 2.2, D5PSS 3). (D) End-of-treatment PET/CT: complete remission (SUVmax of 1.8 at the left iliac/inguinal area, D5PSS 3).