Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effect of the type of substituents occurring in the main structure of aminoalkanol derivatives (I), (II), (III) and (IV) on inhibitory potency (IC50) and affinity strength (Ki) of CAT.
| Compound | R1 | R2 | R3 | Ki [mM] | IC50 [mM] | Docking Energy [kcal/mol] |
|---|---|---|---|---|---|---|
| Derivative (I) |
|
|
|
1.61 | 11.40 | −8.6 |
| Derivative (II) |
|
|
|
3.04 | 12.80 | −8.4 |
| Derivative (III) |
|
|
|
1.32 | 10.30 | −8.9 |
| Derivative (IV) |
|
|
|
1.79 | 12.20 | −8.2 |
