Figure 4.

Resveratrol reduces fructose-induced NADPH oxidase subunit production mediated through a SGLT2−dependent mechanism in the epithelial section of type 2 DM lens. (A,B) Representative images for GLUT5−positive (green) and p47−phox NOX4-positive (red) cells in the lens after resveratrol treatment, compared to no fructose group. Cell nuclei were counterstained in DAPI (blue). (C,D) Quantitative analysis demonstrated that SGLT2 and p67−phox proteins` level were significantly decreased by resveratrol treatment. Values are presented as mean ± SEM (n = 6 per group). Scale bar = 20 μm. * p < 0.05 and ** p < 0.001; ^# p < 0.05 versus Fructose 8 W.