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. 2022 Jun 29;23(13):7252. doi: 10.3390/ijms23137252

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Hemichannels formed by Cys mutants are insensitive to membrane depolarization. Xenopus oocytes were injected with an oligo against the endogenous Cx38 alone (Cx38 -/-) or in combination with cRNA of wild-type Cx46 or Cys mutants. Hemichannel currents were recorded using dual-electrode voltage clamp after 24 h in 8 oocytes. (A) Representative recordings showing that only hemichannels formed of wild-type Cx46 open after membrane depolarization. (B) I/V plot summarizing results of the 8 independent experiments. The Boltzmann equation was used to fit current values.