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. 2022 Jul 2;23(13):7385. doi: 10.3390/ijms23137385

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CDK1 impairs inhibitions of HNSCC cell EMT and migration induced by wild-type ∆Np63α but not those by its T123A mutant. (A) UM1 cells overexpressing CDK1 and (or) ∆Np63α were constructed with lentiviral infection and identified by means of IB analysis. (B) UM1 cells overexpressing CDK1 and (or) ∆Np63α were subjected to transwell assay. Representative crystal violet staining images of migrated cells on the underside were shown. (C) Quantification of effects of CDK1 and (or) ∆Np63α overexpression or ablation on migration ability based on transwell assays (means ± SD, n = 3). One-way ANOVA test was used for comparison between two groups. ***, p < 0.001; **, p < 0.01. (D) The abovementioned cell lines were subjected to RT-qPCR analysis to measure mRNA levels of N-cadherin, vimentin, BPAG and ITGA6 (normalized with GAPDH). The qPCR data are presented as means ± SD (n = 3). ***, p < 0.001; **, p < 0.01; *, p < 0.05.