Figure 7.
Knockdown of ∆Np63α significantly rescues inhibitions of HNSCC cell migration induced by CDK1 depletion. (A) CDK1- and (or) ∆Np63α-knockdown UM1 cells were constructed with lentiviral infection and identified by means of IB analysis. (B) UM1 cells ablated with CDK1 and (or) ∆Np63α were subjected to transwell assay. Representative crystal violet staining images of migrated cells on the underside were shown. (C) Quantification of effects of CDK1 and (or) ∆Np63α ablation on migration ability based on transwell assays (means ± SD, n = 3). ***, p < 0.001; **, p < 0.01.