Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 21;23(13):6878. doi: 10.3390/ijms23136878

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

(A) Lewis structure of SST highlighting the apical FWKT region with red. (B) Homology model of SSTR4 in cartoon representation. D126 (spheres) on TM3 (teal), ECL2 (salmon), and ECL3 (green) are proved to be important in ligand binding and receptor activation. (C) SSTR4 (grey, surface) covered with monolayer of tetrapeptide fragment (Ace–FWKT–NHMe) copies (green, all atom, sticks) at the end of the 7th docking cycle. The best energy fragment is highlighted with spheres (green, all atom).