Figure 1.
SCAP and SREBP-1 expression in NSCLC and normal lung tissues. Representative IHC images used to measure the differential expression of (A) SREBP-1and (B) SCAP in NSCLC tissues from patients with stage I, II, III, and IV disease and in non-tumor lung tissue samples. (C–E) Quantification of SREBP-1 and SCAP expression in non-tumor and tumor lung tissue of different stages, with in-depth analysis of SREBP-1 nuclear localization in lung tissue. (F,G) Expression and correlation of SREBP-1 and SCAP at the mRNA level in NSCLC samples from the GSE18842 lung cancer microarray dataset compared to the normal lung samples. * p < 0.05, *** p < 0.001, and **** p < 0.0001.