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. 2022 Jun 30;23(13):7283. doi: 10.3390/ijms23137283

Figure 2.

Figure 2

SCAP/SREBP lipogenic signaling axis is associated with cisplatin resistance and cancer stemness in NSCLC cells. (A) Comparative MTT assay demonstrating the effect of cisplatin on H441, H441R, A549, and A549R cells. (B) Representative flow cytometry images of the levels of CD133 in H441, H441R, A549, and A549R cells. Graphical representation of the number of (C) spheres and (D) colonies formed by H441, H441R, A549, and A549R cells. (E) Histograms indicating the comparative expression of CD133, SREBP-1, FASN, SCAP, HMGCR, HMGCS, and ABCG2 mRNA in H441, H441R, A549, and A549R cells. All data are represented as means ± SDs from assays performed in triplicate at least 3 times. * p < 0.05.