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. 2022 Jun 30;23(13):7283. doi: 10.3390/ijms23137283

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Enhanced SREBP-1/SCAP/FASN signaling is implicated in the reduced sensitivity of NSCLC cells to cisplatin therapy. (A) The staining intensity scores of the cisplatin-sensitive and cisplatin-resistant samples were compared. Graphical representations in boxplot and micrographs (with p values) indicating the SREBP-1, SCAP, and FASN levels in the cisplatin-sensitive and cisplatin-resistant samples. (B) The qRT-PCR analysis was used to measure the expression of SREBP-1/SCAP/FASN. * p < 0.05, and *** p < 0.001.