Figure 2.

Tau’s diverse physiological roles in the neuron. Initially characterized as a protein required for microtubule assembly and stabilization, it is now recognized that tau has roles in multiple neuronal compartments. Along the axon, tau is involved regulating in bidirectional transport as well as actin filament formation. Nuclear roles include protecting DNA integrity and promoting chromatin relaxation. At the neuronal membrane, tau’s interactions with the NMDA receptor regulate its signaling.