Figure 3.

The lack of a TRPV1 channel affects hepatic functionality, as revealed by the integration data of liver proteomes. (A) The UpSet plot presents the overlapping of proteins found in the liver proteome of Trpv1 KO and WT mice. (B) Scatter plots show the distribution of proteins shared between liver proteomes, indicating downregulated and upregulated proteins in Trpv1 KO mice. LFQ difference denotes log2 (fold change) among groups. (C) Gene ontology biological process (GO-BP) enrichment analyses of differentially identified proteins in the liver proteomes using the annotation of the DAVID database (p < 0.05) are highlighted for lipid metabolism, RNA processing, oxidative stress, and inflammation functional processes that were exclusively expressed in WT or Trpv1 KO animals.