Table 2.

List of 11 exclusively identified kinases, phosphatases, and associated regulator proteins reported to be upstream effectors in each proteome and their correspondingly mapped targets, followed by downstream signaling involved in glycogenesis and glycogenolysis.

Proteins Identified in the Proteomes					Downstream Target Mapped
Genotype	Upstream Effector	Class	Research Source	Function	Target	Class	Research Source	Function	Downstream Signaling
Trpv1 KO	DUSP3	Phosphatase	map04010	Inhibition	MAPK14	Kinase	PSP_454221	Inhibition	GSK3B
Trpv1 KO	MAPK14	Kinase	PSP_454221	Inhibition	GSK3B	Kinase	map04910	Inhibition	GYS2
Trpv1 KO	MAPK14	Kinase	map04068	Activation	FOXO	TF	map04910	Activation	PEPCK, G6PC1, FBP1, FBP2
Trpv1 KO	PTPA	Regulator	Guo et al., 2014	Activation	PP2A complex	Phosphatase	Hernández et al., 2010; Yadav et al., 2017	Activation, Activation, Inhibition	GSK3B, FOXO, AMPK
Trpv1 KO	ENSA	Regulator	Thapa et al., 2020	Inhibition	PP2A complex	Phosphatase	Hernández et al., 2010; Yadav et al., 2017	Activation, Activation, Inhibition	GSK3B, FOXO, AMPK
Trpv1 KO	PRRC1	Regulator	Kotani et al., 2009	Activation	PKA	Kinase	PSP_449111, map04922, Ahn et al., 2007	Inhibition, Inhibition, Activation, Activation	GSK3B, GYS2, PHKB, PP2A complex
Trpv1 KO	ARFGEF2	Regulator	Li et al., 2003	Activation	PKA	Kinase	PSP_449111, map04922, Ahn et al., 2007	Inhibition, Inhibition, Activation, Activation	GSK3B, GYS2, PHKB, PP2A complex
Trpv1 KO	SGK2	Kinase	map04068	Inhibition	FOXO	Transcription factor	map04910	Activation	PEPCK, G6PC1, FBP1, FBP2
WT	MAPK1	Kinase	map04068	Inhibition	FOXO	Transcription factor	map04910	Activation	PEPCK, G6PC1,FBP1, FBP2
WT	ATM	Kinase	PSP_454221	Inhibition	GSK3B	Kinase	map04910	Inhibition	GYS2
WT	PPP2R1B	Phosphatase	map04152	Inhibition	AMPK	Kinase	map04152	Inhibition	GYS2
WT	PPP1CB	Phosphatase	PSP_448786	Inhibition	AMPK	Kinase	map04152	Inhibition	GYS2
WT	PPP1CB	Phosphatase	map04910	Inhibition	PHKB	Kinase	map04922	Activation	PYGL
WT	PPP1CB	Phosphatase	map04910	Activation	GYS2	Kinase	map04922	Glycogen synthase	Glycogen

The research source included the KEGG database (ID: map), PhosphoSitePlus (ID: PSP), and literature data.