Figure 3.

A reduction of I_Ks predicts a larger prolongation in the APD90 following β-adrenergic stimulation. (A). Representative AP waveforms and the corresponding I_Ks for control simulations (black line) and simulations in which the I_Ks component was reduced by 70% (blue line) for basal conditions (left) and β-adrenergic stimulation (right). (B). The steady state duration to 90% AP repolarization (APD₉₀) was plotted as a function of the cycle length for basal conditions (left) or with β-adrenergic stimulation (right). Shown are the corresponding steady-state APD₉₀ calculated for simulations at cycle lengths between 300 and 1000 ms for control simulations (black squares) and simulations in which the I_Ks component was reduced by 70% (blue circles) in basal conditions (left) or conditions that mimic β-adrenergic stimulation (right). The methodology and some of the data for producing these data is adapted from [66].