Figure 1.

Different populations of extracellular vesicles released from almost all cell types. The relative proportion of microvesicles and exosomes is variable and depends on each cell type. Apoptotic bodies contain information from dying cells, such as DNA, fragmented RNA, and organelle material. Mitochondrial DNA has been described in muscle- and adipocyte-derived EVs. Exosomes and microparticles are released by live cells and can target recipient cells either via receptor interactions, direct fusion, or endocytosis/pinocytosis.