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. 2022 Jun 24;23(13):7012. doi: 10.3390/ijms23137012

Figure 3.

Figure 3

The effect of the inhibition of VE-cadherin cleavage pathways on intima-media thickness in C57BL/6J mice. (a) Representative images of aortic cross-sections stained with Hematoxylin-Eosin. (b) Inhibiting HIF-1 (by ACF) prevented the IH-induced elevation of IMT in C57BL/6J mice exposed to IH for 14 days, compared to N (Kruskal-Wallis test, ** p < 0.01 vs. N + vehicle, ### p < 0.001 vs. IH + vehicle, n = 7–8). (c) Inhibiting VEGFR tyr-kinases (by pazopanib) and src-kinases (by saracatinib) prevented the IH-induced elevation of IMT in C57BL/6J mice exposed 14 days to IH, compared to N (Kruskal-Wallis test, ** p < 0.01 vs. N + vehicle, # p < 0.05 vs. IH + vehicle, n = 5–8). (N: normoxia, IH: intermittent hypoxia. Values are median + Interquartile range. Scale bars = 50 µm.