Table 3.
Demographic characteristics of the clinical cohort.
| Diagnostic Groups | |||||||
|---|---|---|---|---|---|---|---|
| Demographic Characteristics | AD | FTD | SCD | ANOVA p-Value |
p-Value SCD vs. FTD |
p-Value SCD vs. AD |
p-Value AD vs. FTD |
| n | 20 | 20 | 20 | - | - | - | - |
| Age | 66 (58, 75) | 64 (61, 68) | 55 (51, 66) | 0.02 | ns | 0.0294 | ns |
| Sex, female | 10 (50%) | 10 (50%) | 5 (25%) | ns | ns | ns | ns |
| MMSE | 21 (11, 25) | 21 (17, 26) | 29 (27, 30) | <0.0001 | <0.0001 | <0.0001 | ns |
| Amyloid-beta 42 | 494 (443, 604) | 846 (723, 1087) | 1036 (870, 1101) | <0.0001 | ns | <0.0001 | <0.0001 |
| Tau | 613 (516, 980) | 385 (265, 482) | 190 (159, 234) | <0.0001 | 0.0031 | <0.0001 | 0.0146 |
| pTau | 83 (61, 111) | 45 (38, 66) | 35 (26, 42) | <0.0001 | 0.0136 | <0.0001 | 0.0064 |
| Nf-L | 899 (702, 1160) | 1880 (1495, 3346) | 409 (292, 578) | <0.0001 | <0.0001 | 0.0057 | 0.0057 |
The data for the sample size are presented as n (%) or as the median (interquartile range). Age is shown in years and the fluid biomarker values are shown as pg/mL. p-Values were calculated using Kruskal–Wallis’ one way ANOVA and Dunn’s multiple comparison. (ns: not significant).