Table 1.
Two-way ANOVA results of Fos quantification in analyzed brain regions following hyperalgesia during spontaneous withdrawal
| Brain region | Treatment effect | Sex effect | Sex × treatment interaction |
|---|---|---|---|
| NAc shell | F(1,19) = 0.8349, p = 0.3723 | F(1,19) = 10.41, p = 0.0044; F > M | F(1,19) = 0.05892, p = 0.8108 |
| BNST | F(1,19) = 1.926, p = 0.1813 | F(1,19) = 4.275, p = 0.0526 | F(1,19) = 0.4395, p = 0.5153 |
| PVN | F(1,19) = 30.16, p < 0.0001 | F(1,19) = 8.964, p = 0.0075; F > M | F(1,19) = 0.2445, p = 0.1344 |
| PVT | F(1,19) = 0.1164, p = 0.7367 | F(1,19) = 2.544, p = 0.1272 | F(1,19) = 0.2627, p = 0.6142 |
| LH | F(1,19) = 16.93, p < 0.001 | F(1,19) = 5.546, p = 0.0294; F > M | F(1,19) = 0.1327, p = 0.7197 |
| CeA | F(1,19) = 26.37, p < 0.0001 | F(1,19) = 1.876, p = 0.1867 | F(1,19) = 0.09373, p = 0.7628 |
| LHb | F(1,19) = 40.80, p < 0.0001 | F(1,19) = 8.195, p = 0.0100; F > M | F(1,19) = 0.9071, p = 0.3528 |
| PAG | F(1,19) = 1.136, p = 0.2998 | F(1,19) = 8.589, p = 0.0086; F > M | F(1,19) = 0.005, p = 0.9441 |
| SUM | F(1,19) = 4.195, p = 0.0546 | F(1,19) = 14.44, p = 0.0012; F > M | F(1,19) = 0.007174, p = 0.9334 |
| VTA | F(1,19) = 27.39, p < 0.0001 | F(1,19) = 5.773, p = 0.0267; F > M | F(1,19) = 0.1231, p = 0.2810 |
| DR | F(1,19) = 11.70, p < 0.01 | F(1,19) = 1.803, p = 0.1952 | F(1,19) = 0.08641, p = 0.3642 |
| PBN | F(1,19) = 26.15, p < 0.0001 | F(1,19) = 0.2822, p = 0.6014 | F(1,19) = 0.1759, p = 0.6796 |
| LC | F(1,19) = 17.91, p < 0.001 | F(1,19) = 0.5460, p = 0.4695 | F(1,19) = 0.5909, p = 0.4520 |
Males (M), Females (F).