Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 28;23(13):7155. doi: 10.3390/ijms23137155

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

CD4+ T cell reactivity as a function of donor sex and age. The cohort of 89 acute COVID-19 donors was analyzed for CD4+ T cell responses to SARS-CoV-2 S by AIM + ICS assays. (A) The spike-specific AIM+ and IFNγ+ CD4+ T cell responses are shown for the entire cohort as a function of donor sex (male in white and female in dark grey). The y-axis begins at the LOD for each assay and the dotted line represents the LOS. Mann–Whitney U tests were applied to the data and the results are indicated by symbols when significant. (B) The CD4+ AIM and IFNγ reactivity to S is shown as a function of donor age. Mild (n = 21, blue), moderate (n = 35, yellow), and severe (n = 33, red) disease states are plotted together. R and p-values are calculated by Spearman correlation.