Figure 2.

Potential neuroprotective interventions that have been shown to affect the ferroptosis-related pathways in studies of neonatal hypoxic-ischemic brain injury. Other interventions that have been trialed in adult populations but not yet neonates are described in the text but not included in the figure. The double arrows represent byproducts that can further potentiate the initial process (e.g., TLR4 is increased from the process of ferroptosis but TLR4 appears to also activate ferroptosis). CoQ₁₀, coenzyme Q₁₀; DAMPs, damage associated molecular patterns; EPO, erythropoietin; FSP1, ferroptosis suppressor protein 1; GPX4, glutathione peroxidase 4; HMGB1, high mobility group box 1; TLR4, toll-like receptor 4.