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. 2022 Jul 5;23(13):7482. doi: 10.3390/ijms23137482

Figure 2.

Figure 2

TCR-Vβ usages in SAGN with IgA-dominant deposition. Peripheral blood mononuclear cells (PBMCs) obtained from patients with SAGN, S. aureus-infected patients without glomerulonephritis, and healthy controls stained with fluorescence-labeled monoclonal antibodies against 17 types of TCR-Vβ (6 of 17 types of TCR-Vβ were reported [3,9,10,11,12,13], and the other 11 types are unpublished data); Vβ5.1 (Vβ5c), Vβ5.2+5.3 (Vβ5a), Vβ 5.3 (Vβ5b), Vβ6.7 (Vβ6a), Vβ8 subfamily (Vβ8a) and Vβ12.1 (Vβ12a), Vβ2, Vβ3 (Vβ3a), Vβ11, Vβ13 (Vβ13a), Vβ13.6, Vβ14, Vβ16, Vβ17, Vβ20, Vβ21.3, and Vβ22. The stained PBMCs were then analyzed using flow cytometry. The percentages of 17 TCR-Vβ-positive cells among circulating CD3-positive cells are shown. Black closed circles: the mean percentages of cells in patients with SAGN. Gray closed circles: the mean percentages of cells in S. aureus-infected patients without glomerulonephritis. Open circles: the mean percentages of cells in healthy controls. Bars: the standard deviation of positive cells. The percentages of Vβ8- and Vβ12.1-positive cells in the SAGN patients were significantly increased compared to those in the controls, and the percentages of Vβ8-positive cells in the patients with SAGN were significantly higher compared to those in patients without glomerulonephritis (* p < 0.05; ** p < 0.005).