Table 4.
Histological findings of the reported patients with IgA-IRGN or SAGN.
| IgA-IRGN n = 336 |
SAGN n = 218 |
|||
|---|---|---|---|---|
| Light microscopy: | ||||
| Mesangial hypercellularity | 73.9% | 209/283 | 64.1% | 66/103 |
| Endocapillary proliferation | 71.7% | 203/283 | 58.6% | 106/181 |
| Membranoproliferative GN | 5.9% | 16/270 | 7.8% | 8/103 |
| Necrotizing/crescentic GN | 9.1% | 21/231 | 10.7% | 11/103 |
| Presence of crescents | 56.1% | 143/255 | 47.6% | 78/164 |
| Immunofluorescence: | ||||
| Positive staining with IgG | 44.4% | 118/266 | 51.3% | 79/154 |
| Positive staining with IgA | 100.0% | 303/303 | 85.1% | 149/175 |
| Positive staining with C3 | 97.0% | 291/300 | 90.4% | 161/178 |
| Electron microscopy: | ||||
| Subepithelial EDD | 54.3% | 119/219 | 40.5% | 62/153 |
| Subendothelial EDD | 43.1% | 81/188 | 47.1% | 33/70 |
| Intramembranous EDD | 15.6% | 31/199 | 6.9% | 4/58 |
| Mesangial EDD | 78.2% | 147/188 | 85.3% | 64/75 |
| Humps | 37.5% | 90/240 | 31.7% | 46/145 |
EDD—electron dense deposit; GN—glomerulonephritis.