Figure 1.

Associations of baseline characteristics with serum calcification propensity T50 in PXE. T50 significantly correlated with age (panel (A)), but not with sex or ABCC6 genotype (panels (B,C)). Serum fetuin-A levels correlated strongly and positively with T50 (panel (D)). An inverse correlation existed between T50 and serum phosphorus levels (panel (E)), while only a trend towards correlation was identified with serum magnesium levels in univariate analysis (panel (F)). Plasma inorganic pyrophosphate did not significantly correlate with serum T50 in PXE patients (panel (G)). LOF—loss-of-function variants; MIS—missense variants; ns—non significant.