Table 3.
Correlations of heart rate variability parameters with echocardiographic parameters of LV systolic and diastolic function for baseline absolute values and changes (delta) after 12-month treatment.
| Baseline—R (Correlation Coefficient) | |||||
|---|---|---|---|---|---|
| HRV Parameters | LVEF | E/A | e’ | E/e’ | GLS |
| SDNN_24 h (ms) | −0.01 | 0.36 # | 0.23 ** | −0.03 | −0.09 |
| rMSSD_24 h (ms) | −0.05 | 0.41 # | 0.24 ** | −0.04 | −0.01 |
| pNN50_24 h (%) | −0.07 | 0.44 # | 0.23 ** | −0.01 | −0.01 |
| TP_day (ms2) | 0.06 | 0.32 # | 0.26 ** | −0.17 | −0.09 |
| TP_night (ms2) | −0.17 * | 0.28 ** | 0.23 ** | −0.06 | 0.03 |
| Change after Treatment (Delta)—R (Correlation Coefficient) | |||||
| HRV Parameters | LVEF | E/A | e’ | E/e’ | GLS |
| SDNN_24 h (ms) | 0.14 | 0.10 | 0.15 | −0.09 | 0.06 |
| rMSSD_24 h (ms) | 0.25 ** | 0.34 # | 0.13 | −0.03 | 0.19 |
| pNN50_24 h (%) | 0.22 * | 0.38 # | 0.18 | −0.03 | 0.16 |
| TP_day (ms2) | 0.09 | 0.07 | 0.09 | −0.07 | −0.04 |
| TP_night (ms2) | 0.14 | 0.17 | 0.10 | −0.06 | 0.03 |
Statistically significant correlations: * p < 0.05; ** p < 0.01; # p < 0.001. delta—change after 12-month treatment; e’—mitral septal annulus early diastolic velocity; E/A—the ratio of the early (E) and late (A) mitral flow; E/e’—the ratio of early mitral flow (E) and mitral septal annulus early diastolic velocity (e’); GLS—global longitudinal strain; HF—high frequency; HRV—heart rate variability; LF—low frequency; LVEF—left ventricular ejection fraction; ns—not statistically significant; n.u.—normalized units; pNN50—the proportion of pairs of successive NN intervals that differ by more than 50 ms; rMSSD—the square root of the mean of the sum of the squares of differences between adjacent NN intervals; SDNN—standard deviation of the average of NN intervals; TP—total power.