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. 2021 Jul 27;13(607):eabh0755. doi: 10.1126/scitranslmed.abh0755

Fig. 2. Lung pathology is reduced in ChAdOx1 nCoV-19 IN-vaccinated Syrian hamsters after direct IN challenge with SARS-CoV-2.

Fig. 2.

(A) Hematoxylin and eosin (H&E)–stained lung sections from control hamsters 5 days after SARS-CoV-2 infection reveals moderate to marked interstitial pneumonia. (B and C) H&E-stained sections of lungs isolated from IN-vaccinated (B) or IM-vaccinated (C) hamsters reveal no pathology after infection. (D) Numerous immunoreactive (brown) bronchiolar epithelial cells and types I and II pneumocytes are observed in control hamsters. (E and F) No immunoreactivity is present in sections of lungs isolated from IN-vaccinated (E) or IM-vaccinated (F) hamsters. Scale bars, 50 μm.