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. 2021 Jul 27;13(607):eabh0755. doi: 10.1126/scitranslmed.abh0755

Fig. 4. Lung pathology is reduced in ChAdOx1 nCoV-19 IN-vaccinated Syrian hamsters cohoused with SARS-CoV-2 infected hamsters.

Fig. 4.

(A) H&E-stained lung sections from control hamsters 5 days after SARS-CoV-2 infection reveal moderate to marked interstitial pneumonia. (B) H&E-stained sections of lungs isolated from IN-vaccinated hamsters reveal no pathology after infection. (C) H&E-stained sections of lungs isolated from IM-vaccinated hamsters reveal mild interstitial pneumonia after infection. (D) Numerous immunoreactive (brown) bronchiolar epithelial cells and types I and II pneumocytes are observed in control hamsters. (E) No immunoreactivity is present in sections of lungs isolated from IN-vaccinated. (F) Scattered immunoreactive bronchiolar epithelial cells and types I and II pneumocytes are observed in IM-vaccinated hamsters. Scale bars, 50 μm.