Table 3.

Associations of biomarkers with disease progression by areas under ROC curves.

	Area under Curve	p-Value	Cut-off for 90% Sensitivity
CRP	0.827	<0.001	2.73
CD4+ T cells, % *	0.718	0.016	64.8
Total lymphocytes *	0.702	0.026	2100
CD4/CD8 *	0.692	0.034	3.23
CD8+ HLADR T cell MFI	0.670	0.060	624
CD8+ T cells, %	0.659	0.079	22.2
CD8+ NKG2A T cell MFI	0.650	0.097	2054
Monocytes	0.644	0.112	**
B lymphocytes	0.643	0.115	**
T lymphocytes	0.636	0.132	**
NK cells	0.601	0.265	**
CD8+ HLADR- CD38+ T cells	0.597	0.283	**
CD8+ CD38+ T cells	0.592	0.312	**
CD8+ HLADR+ CD38+ T cells	0.585	0.350	**
NK-NKG2A cells	0.570	0.438	**
NK-NKG2A cell MFI	0.567	0.459	**
CD8+ NKG2A+ T cells	0.554	0.549	**
CD8+ CD38+ T cell MFI	0.551	0.577	**
CD8+ HLADR- CD38- T cells	0.548	0.596	**
CD8+ HLADR+ T cells	0.541	0.651	**
CD8+ HLADR+ CD38- T cells	0.534	0.707	**

CRP, C-reactive protein; HLA-DR, human leukocyte antigen DR isotope; MFI, mean fluorescent intensity; NK, natural killer; NKG2A, natural killer group 2-member A. * For total lymphocytes, CD4+ T cells and CD4/CD8, reduced values are predictors of disease progression. ** Not calculated due to lack of statistical association at 10% significance level. Bold values indicate AUC ≥ 0.650.