Table 2.

The summary of findings for the SONIC [31] study. Results of the SONIC trials. All values are in means (SD).

Study Id and Registration Number	Intervention and Comparator	Dosage and Frequency	Results for	Intervention	Azathioprine	p Value	Conclusion
SONIC [31] NCT00094458	Infliximab (IV) and azathioprine (oral)	Infliximab 5mg/kg given at week 2,4,6 and then every 8 weeks OR azathioprine 2.5 mg/kg	Mean IBDQ at baseline	126.7 (30.3)	128 (29)	-	Non-inferiority trial favoured infliximab over azathioprine in improving HRQoL.
			Change at week 2	27.2 (26.1)	20.1 (24.3)	0.007
			Change at week 6	34.8 (31.8)	28.3 (31.3)	0.10
			Change at week 10	37.8 (35.6)	31.0 (31.7)	0.10
			Change at week 18	39.9 (34.2)	30.3 (33.9)	0.01
			Change at week 26	39.9 (36.6)	31.4 (35.4)	0.05
			Change at week 32 *	55.8 (33.6)	39.1 (32.9)	0.001
			Change at week 42 *	51.4 (32.8)	40.3 (32.1)	0.04
			Change at week 50 *	51.6 (32.9)	43.0 (33.4)	0.09

* SONIC extension for maintenance therapy.