Table 2.

Inclusion and exclusion criteria for selecting studies in the systematic review.

Inclusion Criteria	Exclusion Criteria
Study design: Randomized controlled trials, clinical studies, observational studies (Retrospective study)	Case reports, comments, conference proceedings
Patients with immature necrotic permanent teeth	Studies experimenting on vital teeth
Studies in which either one of the interventions or both are compared	Animal studies, case reports, in vitro studies, laboratory studies
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