Table 2.
Median (lower quartile–upper quartile) of hemodynamic and autonomic parameters for MG patients and healthy controls.
| Group | MG | HC | MG | HC | MG | HC |
|---|---|---|---|---|---|---|
| Rest | 70° Tilt | Change after 70° Tilt (Delta) | ||||
| Hemodynamic measures | ||||||
| HR [1/min] | 62.5 (59.8,69.7) | 68.8 (61.5,71.1) | 75.6 (69.9,83.6) | 82.2 (75.8,86.9) | 10.4 (6.7,16.9) | 14.3 (10.4,18.1) |
| sBP [mmHg] | 113.0 (106.7,120.2) | 110.0 (103.0,121.2) | 120.2 (116.7,126.6) | 122.8 (117.5,132.9) | 6.0 (1.6,19.4) | 14.3 (6.7,20.0) |
| dBP [mmHg] | 72.6 (67.5,75.9) | 73.7 (66.9,78.0) | 85.7 (78.5,88.9) | 89.9 (83.3,92.9) | 12.4 (7.8–17.0) | 15.8 (8.5,21.2) |
| mBP[mmHg] | 89.7 (85.0,93.9) | 90.9 (81.3,97.7) | 99.1 (95.5,104.8) | 103.8 (97.2,110.3) | 10.6 (5.6,16.0) | 14.4 (8.8,21.1) |
| SI [ml/m2] | 55.3 (44.1,61.1) | 59.2 (51.1,66.0) | 39.0 (34.5,42.5) | 41.2 (36.7,45.6) | −16.2 (−20.3,−9.1) | −17.7 (−22.9,−13.6) |
| CI [l/min/m2] | 3.4 (2.9,3.9) | 3.8 (3.2,4.4) * | 2.9 (2.5,3.3) | 3.3 (3.0,3.8) * | −0.5 (−0.8,−0.2) | −0.6 (−0.8,−0.5) |
| TPRI [dyn × s m2/cm5] | 20004.7 (1838.9–2428.6) | 1838.0(1582.6,2167.8) * | 2627.9 (2365.2,3250.5) | 2458.6 (2136.3,2921.7) | 613.0 (249.6,928.3) | 670.0 (392.8,1004.8) |
| LVWI [kg m/min/m2] | 3.9 (3.5,4.6) | 4.6(4.0,5.2) * | 3.8 (3.5,4.4) | 4.7 (4.1,5.1) * | −0.2 (−0.5,0.2) | 0.0 (−0.5,0.4) |
| IC [1000/s] | 63.7 (46.2,78.6) | 74.3 (56.2,92.0) * | 46.8 (35.9,53.9) | 52.9 (44.0,62.2) | −18.7 (−28.0,−6.9) | −23.9 (−31.1,−17.4) |
| EDI [ml/m2] | 85.8 (69.8,100.7) | 96.1 (79.7,107.6) | 69.8 (61.3,76.5) | 75.6 (67.3,84.2) | −18.6 (−25.7,−8.7) | −21.1 (−28.1,−12.9) |
| TFC [1/kOhm] | 27.1 (24.1,29.9) | 32.6 (28.7,34.6) * | 24.6 (22.6,27.5) | 29.4 (26.6,32.1) | −2.2 (−2.7,−1.5) | −2.9 (−3.3,−2.2) * |
| Heart rate variability (HRV) | ||||||
| LFnu-RRI [ms2] | 61.1 (46.8,73.8) | 58.5 (49.2,65.4) | 82.9 (67.4,89.5) | 76.9 (65.0,81.7) | 17.6 (11.1,29.4) | 12.9 (6.3,22.5) |
| HFnu-RRI [ms2] | 38.9 (26.2,53.2) | 41.5 (34.6,50.8) | 17.1 (10.5,32.6) | 23.1 (18.3,35.0) | −17.6 (−29.4,−11.1) | −12.9 (−22.5,−6.3) |
| LF-RRI [ms2] | 570.3 (310.3,1240.6) | 614.8 (392.4,1117.0) | 331.6 (217.9,755.1) | 585.7 (291.1,1262.7) * | −85.1 (−543.7,30.0) | −78.1 (−220.6,232.2) |
| HF-RRI [ms2] | 289.3 (102.6,1012.5) | 364.0 (198.9,882.1) | 90.9 (32.5,183.7) | 230.8 (92.9,324.4) * | −172.4 (−797.3,−67.1) | −161.5 (−640.6,−49.4) |
| PSD-RRI [ms2] | 1246.8 (709.4,2843.7) | 1420.4 (855.8,2458.8) | 762.9 (403.7,1362.7) | 1080.1 (615.1,2096.2) | −447.7 (−1754.4,−145.9) | −443.5 (−1088.6,−57.8) |
| LF/HF-RRI [1] | 1.7 (0.9,3.0) | 1.5 (1.0,2.0) | 5.2 (2.2,9.4) | 3.4 (1.9,5.0) | 3.4 (1.4,6.3) | 1.7 (0.6,3.1) * |
| LF/HF [1] | 1.1 (0.7,1.8) | 1.1 (0.9,1.5) | 3.0 (1.3,5.5) | 2.5 (1.3,3.6) | 1.8 (0.4,4.2) | 1.2 (0.4,2.5) |
| Systolic Blood pressure variability (SBPV) | ||||||
| LFnu-sBP [%] | 41.2 (31.9,48.1) | 40.2 (35.7,45.8) | 51.1 (41.3,62.2) | 46.5 (38.1,54.7) | 10.1 (4.8,17.1) | 11.0 (1.0,17.6) |
| HFnu-sBP [%] | 12.5 (9.0,19.6) | 10.7 (6.9,15.4) | 15.0 (10.7,20.4) | 13.6 (8.3,18.4) | 1.6 (−0.8,3.7) | 2.1 (−0.0,3.2) |
| LF-sBP [mmHg2] | 4.5 (3.4,8.0) | 3.6 (2.9,7.2) | 4.2 (2.7,6.6) | 3.4 (2.1,6.3) | −0.3 (−1.6,0.4) | −0.4 (−1.6,0.1) |
| HF-sBP [mmHg2] | 1.4 (1.0,2.9) | 1.1 (0.6,1.7)* | 1.1 (0.9,2.3) | 1.0 (0.5,1.6) | −0.2 (−0.5,0.0) | −0.1 (−0.5,0.0) |
| PSD-sBP [mmHg2] | 12.1 (7.8,17.3) | 10.4 (7.7,15.7) | 8.4 (6.3,11.9) | 7.8 (5.7,12.4) | −2.6 (−6.7,−1.1) | −2.6 (−5.2,−1.2) |
| LF/HF-sBP [1] | 2.8 (1.9,4.5) | 4.1 (2.9,5.5) * | 3.3 (2.1,5.0) | 4.0 (2.4,5.2) | 0.0 (−0.4,0.7) | 0.1 (−0.7,0.6) |
| BRS [ms/mmHg] | 12.0 (8.4,20.3) | 19.4 (12.8,25.2) * | ||||
Myasthenya gravis (MG), healthy controls (HC), heart rate (HR), systolic blood pressure (sBP), diastolic blood pressure (dBP), mean blood pressure (mBP), stroke index (SI), cardiac index (CI), total peripheral index (TPRI), left ventricular work index (LVWI), thoracic fluid content (TFC), end-diastoic index (EDI), index of contractility (IC), low frequency R-R interval (LF-RRI), high-frequency R-R interval (HF-RRI), power spectral density R-R interval (PSD-RRI), ratio between low and high band for heart rate variability (LF/HF-RRI) ratio between low and high band for heart rate and blood pressure variability (LF/HF), power spectral density of systolic blood pressure variability (PSD-sBP), low frequency of systolic blood pressure variability (LF-sBP), high frequency of systolic blood pressure variability (HF-sBP), power spectral density of diastolic blood pressure variability (PSD-sBP), the ratio between low and high band for systolic blood pressure variability (LF/HF-sBP), baroreflex sensitivity (BRS); nu, normalised values; statistically significant differences are indicated with * p < 0.05.